Creon contain Pancreatin. Pancreatin is a mixture of the fat dissolving enzyme, lipase, the protein enzymes such as protease, and those that break down carbohydrates like amylase. The enzymes in pancreatin may come from pork, beef or vegetables.
A obstruction in the pancreatic duct, or removal of part of the pancreas, can cause a change in the flow and amount of pancreatic juice. Pancreatic juice contains enzymes that help the body to digest and absorb nutrients such as fat, carbohydrate and protein.
If your body cannot create enough pancreatic juice, you will have trouble getting nourishment from foods and eventually you will lose weight. Taking a pancreatic enzyme supplement can improve the absorption of nutrients from the digestive system, help nutrition and prevent weight loss.
Pancreatin is used to treat a lack of pancreas secretion. This may occur in chronic pancreatitis, cystic fibrosis, or in any condition such as surgery or cancer where the pancreas duct is blocked and enzymes cannot reach the intestine.
When not to take enzyme supplements :On an empty stomachWith drinks that contain less than half milk – such as tea, non-milky coffee, fruit squashes and fizzy drinksIf you eat small quantities of fruit, vegetables, dried fruit, fat-free sweets (jelly babies, wine gums, mints)If you take a very small quantity of foods such as an individual chocolate/square of chocolate bar or a small plain biscuit
A Dietitian may provide suggestion or supplementary information on managing your diet.
The dose of pancreatin must be adjusted according to the needs of the individual patient.
Initially one Creon 25 000 capsule should be taken, with liquid, with meals. If necessary, the dosage can be increased.
Children with cystic fibrosis who are taking, or have been given in excess of 10 000 units of lipase/kg/day are at risk of developing colon damage.
The capsule should be swallowed whole, without chewing. Alternatively the capsule may be opened and the pellets administered without the shell from a spoon. The pellets should not be chewed.
Side effects :
Adverse reactions can happen with any drug, even over-the-counter medicine. Some of these are mild such as a stomach upset, which may be avoided by taking the drug with food. Minor reactions may go away on their own but if they continue, contact the physician. For major reactions, the patient should contact the physician instantly.
For pancreatin, the following are the observed side effects :
Minor :stomach crampsnauseadiarrheaskin rashallergic reaction